Expression of hMLH1 and hMSH2 proteins in ameloblastomas and tooth germs
نویسندگان
چکیده
منابع مشابه
Microsatellite instability and hMLH1 and hMSH2 expression in renal tumors.
Defects in the function of mismatch repair (MMR) genes result in genetic instability, a common feature of malignant progression. This study was conducted to determine the frequency of genetic instability [defined as microsatellite instability (MSI)] and to evaluate the sensitivity/specificity of immunohistochemistry in predicting the deficiency in MMR genes in renal cortical tumors. A total of ...
متن کاملLink between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis*
BACKGROUND The studies found in the literature associate the immunoexpression of hMLH1 and hMSH2 proteins with histologic aspects, but do not correlate it with clinical and epidemiological data. OBJECTIVE To evaluate the immunoexpression of hMLH1 and hMSH2 in actinic cheilitis, correlating it with clinical characteristics. METHODS We analyzed 40 cases. Histological and immunohistochemical a...
متن کاملDifferential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair.
Defects in DNA mismatch repair have been associated with both hereditary and sporadic forms of cancer. Recently, it has been shown that human cell lines deficient in mismatch repair were also defective in the transcription-coupled repair (TCR) of UV-induced DNA damage. We examined whether TCR of ionizing radiation-induced DNA damage also requires the genes involved in DNA mismatch repair. Cells...
متن کاملImmunohistochemical analysis of hMLH1 and hMSH2 proteins in serous ovarian tumours.
Inactivation of DNA mismatch repair (MMR) genes is involved in carcinogenesis of sporadic and inherited human cancers. Mutations in MMR genes are associated with the loss of immunoexpression of hMLH1 and hMSH2 and may play a role in the mechanism of carcinogenesis of ovarian tumours. The aim of the study was to evaluate the immunoexpression of hMLH1 and hMSH2 in serous ovarian tumours. Sixty ca...
متن کاملDeficiency of hMLH1 and hMSH2 expression is a poor prognostic factor in Early Gastric Cancer (EGC)
Purpose: The aim of the study was to investigate the effect of deficiency of hMLH1 and hMSH2 expression on the prognosis of early gastric cancer (EGC) in Chinese populations. Methods: A total of 160 EGC patients who underwent curative gastrectomy with lymphadenectomy from January 2011 to July 2014 at Xinhua Hospital were evaluated. The expression rates of hMLH1 and hMSH2 were examined using tis...
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ژورنال
عنوان ژورنال: Medicina Oral Patología Oral y Cirugia Bucal
سال: 2018
ISSN: 1698-6946
DOI: 10.4317/medoral.22210